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Back to the Journal The clinical effects of insertion torque for implants placed in healed ridges: A two-year randomized controlled clinical trial January 6, 2017 / Categories: Digital Dentistry, Implant Dentistry Alfonsi, Fortunato Borgia, Valentina Barbato, Luigi Tonelli, Paolo Giammarinaro, Enrica Marconcini, Simone Romeggio, Stefano Barone, Antonio Several factors are involved in the achievement of implant primary stability, such as the insertion torque, the implant’s macrogeometry, the surgical technique, and the bone quality and quantity. Implant primary stability is considered one of the key factors for osseointegration and is associated with insertion torque. Introduction Several studies have suggested that insertion torque values of 25–45 N cm could prevent micromovements that could impair the bone healing around the implants. The aim of the present randomized clinical trial was to evaluate and compare the ...
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  ORIGINAL ARTICLE Early Treatment for Covid-19 with SARS-CoV-2 Neutralizing Antibody Sotrovimab List of authors. Anil Gupta, M.D.,  Yaneicy Gonzalez-Rojas, M.D.,  Erick Juarez, M.D.,  Manuel Crespo Casal, M.D.,  et al.,  for the COMET-ICE Investigators * October 27, 2021 DOI: 10.1056/NEJMoa2107934 Article Figures/Media Metrics 27  References Abstract BACKGROUND Coronavirus disease 2019 (Covid-19) disproportionately results in hospitalization or death in older patients and those with underlying conditions. Sotrovimab is a pan-sarbecovirus monoclonal antibody that was designed to prevent progression of Covid-19 in high-risk patients early in the course of disease. METHODS In this ongoing, multicenter, double-blind, phase 3 trial, we randomly assigned, in a 1:1 ratio, nonhospitalized patients with symptomatic Covid-19 (≤5 days after the onset of symptoms) and at least one risk factor for disease progression to receive a single infusion of sotrovimab at a...
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Perspective The Future of SARS-CoV-2 Vaccination — Lessons from Influenza List of authors. Arnold S. Monto, M.D. November 6, 2021 DOI: 10.1056/NEJMp2113403 Article Figures/Media Metrics 5  References Comment  Comments  open through November 17, 2021 Article After a period of falling Covid-19 illness rates, the recent spread of the delta variant of SARS-CoV-2 was a major disappointment and necessitated a reexamination of some previous assumptions. This reconsideration may, at least in part, be a correction to overly optimistic views of what highly effective SARS-CoV-2 vaccines could accomplish. Some observers had hoped the vaccines could eliminate transmission of the virus, the ultimate goal of reaching herd immunity. 1  A more likely picture of our future with this virus comes into focus if we examine the well-known infection patterns of another respiratory virus, influenza, both in and outside pandemics. That experience can help us reset expectations and modify goal...
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